The IRIS NeuroStudy aims to assess the long-term neuropsychiatric and neuropsychological dysfunctions associated with COVID-19 from an interdisciplinary perspective.

 

The proposed human subjects study leverages interdisciplinary expertise across the medical school to address the urgent need to understand the mechanisms by which the SARS-CoV-2 infection may impact long-term neuropsychiatric and neuropsychological functions. There are increasing reports of post-infection ‘brain fog’ characterized by poor concentration, anxiety, and sleep disruptions, even when physical COVID symptoms were mild.

 

Our IRIS study represents a landmark study in addressing these possibilities in depth. The knowledge generated will have the potential to help elucidate the root cause of ‘brain fog’ post-infection, yield new brain-based tools for diagnosing COVID-19-related neuropsychiatric sequelae, and identify selective mechanistic targets for novel interventions that will ultimately help ameliorate these effects.